Inhibition of the B Cell by CD22: A Requirement for Lyn
نویسندگان
چکیده
Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies. We find that in the absence of Lyn, the ability of CD22 to become tyrosine phosphorylated after ligation of mIg, to recruit SHP-1, and to suppress mIg-induced elevation of intracellular [Ca2+] is lost. Therefore, Lyn is required for the SHP-1-mediated B cell suppressive function of CD22, accounting for similarities in the phenotypes of these mice.
منابع مشابه
Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 187 شماره
صفحات -
تاریخ انتشار 1998